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August 1, 1936


JAMA. 1936;107(5):356. doi:10.1001/jama.1936.02770310034013

Bence Jones protein is an albuminous substance which appears in the urine under certain pathologic conditions. The material is characterized by precipitation at a relatively low temperature (from 40 to 50 C.) and resolution as the temperature of the medium approaches the boiling point. The presence of this protein in the urine has been of clinical aid in the diagnosis of multiple myeloma. This protein material escapes catabolism and passes the kidneys in amounts so great that the nitrogen excreted in this form may amount to a third or more of the total nitrogen excreted.

Although it is a highly complex substance forming colloidal solutions, it may be passed in large quantities for long periods by kidneys which remain impervious to plasma proteins and which are, to all appearances at least, histologically intact. The question of the origin of Bence Jones protein is of particular interest. Is the protein of

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