The relation of the ubiquitous streptococcus to specific disease processes is one of the most difficult problems in bacteriologic and immunologic research. The essential problem is how to differentiate the pathogenic from the nonpathogenic forms. Various methods have been studied with this aim in view, but thus far no thoroughly adequate method has been described.
A further attempt to advance the solution has recently been reported in a series of studies by Chapman and his co-workers.1 The strains of streptococci used in their investigations were isolated from suspected foci of infection of patients with chronic diseases. After purified substrains were obtained, certain in vitro tests were applied. One of the earliest tests was the so-called bactericidin reaction, which was an attempt to correlate the resistance of streptococci to the "bactericidal" action of fresh, defibrinated guinea-pig blood. In the investigations reported other substances, notably sodium carbonate, sodium bicarbonate, phenol, basic
RECENT INVESTIGATIONS ON STREPTOCOCCI. JAMA. 1936;107(8):588–589. doi:10.1001/jama.1936.02770340040010
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