Clinically the diagnosis of major trigeminal neuralgia is not difficult. A vicious lancinating, paroxysmal pain in either side of the face referred to the tongue or teeth, the upper or lower lip, nose or forehead in man or woman of 50 or 60, especially if a characteristic burst of pain can be excited by slight irritation of a particular point on the tongue, lips or cheek, constitutes briefly the syndrome called tic douloureux. Relief from this dreadful pain can be afforded only by blocking the sensory pathways in the trigeminal nerve either peripheral to the gasserian ganglion or between the ganglion and the brain stem.
Surgical measures to sever the sensory root of the fifth nerve have been repeatedly described and standardized, but the value of peripheral block with alcohol of the appropriate branch of the trigeminal nerve as a means for relieving the pain of tic douloureux and as
GRANT FC. ALCOHOL INJECTION IN THE TREATMENT OF MAJOR TRIGEMINAL NEURALGIA. JAMA. 1936;107(10):771–774. doi:10.1001/jama.1936.02770360017006
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