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October 22, 1955


JAMA. 1955;159(8):771-773. doi:10.1001/jama.1955.02960250033007

Studies of total circulating hemoglobin and protein1 suggest that a similar quantitation of plasma sodium might be helpful in patients with sodium imbalances. This is a preliminary report of plasma volume and serum sodium determined simultaneously in patients with clinical evidence of water and electrolyte disturbances. These investigations indicate the desirability of knowing the state of the plasma volume as well as concentration of sodium for optimum diagnostic and therapeutic perspective in patients with suspected alterations of circulating sodium.

MATERIALS AND METHODS  Studies were performed on 13 normal subjects and 92 patients with body sodium abnormalities. Fluid and electrolyte disturbances were due to cirrhosis of the liver in 22 patients; heart failure in 21 patients; renal insufficiency in 21 patients; systemic disease with dehydration, fluid accumulation, or acid-base imbalance in 21 patients; and intestinal disease in 7 patients. Plasma volume was determined with standardized Evans blue, T-1824, by use