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September 26, 1936

TREATMENT OF DEMENTIA PARALYTICA: COMPARATIVE STUDY OF COMBINED ARTIFICIAL HYPERPYREXIA AND TRYPARSAMIDE VERSUS THERAPEUTIC MALARIA: A PRELIMINARY REPORT

JAMA. 1936;107(13):1031-1036. doi:10.1001/jama.1936.02770390023008
Abstract

This communication is a preliminary report of a long term study of the comparative value of combined artificial fever and tryparsamide versus therapeutic malaria in the treatment of dementia paralytica. Tryparsamide and heavy metal chemotherapy were administered in the follow-up care of the sixty patients observed in both series.

From the time of Wagner von Jauregg's original report in 1917 on the therapeutic value of malarial fever in the treatment of dementia paralytica there have been many confirmatory publications from European and American medical centers. There is no doubt that malaria is distinctly beneficial in combating this disease, but many workers are of the opinion that the procedure leaves much to be desired. In 1929 Neymann and Osborne1 and later, in March 1930, King and Cocke2 reported successful treatment of dementia paralytica with pyretotherapy produced by diathermy and stated that their results compared favorably with those obtained from

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