Routine cross matching of donor's cells with recipient's serum for demonstration of acquired isoagglutinins is inadequate. Since the transfusion service of this institution was centralized in November 1943 and all reactions were subjected to complete investigation by the personnel of the blood bank, nearly 1,000 transfusions have been given without evidence of a single reaction due to intergroup incompatibility. However, during this period there have been observed in 3 female patients 5 hemolytic reactions, all of which were due to acquired sensitivity to the Rh factor. In each instance cross matching had been carried out by the test tube centrifuge method, first at room temperature and later at refrigerator and body temperatures, without detecting incompatibility. This inability to predict intragroup reactions is due to the fact that many times the acquired Rh antibody is not demonstrable by in vitro tests.
The transfusion reactions which occurred in this hospital during the
YOUNG LE, KARIHER DH. HEMOLYTIC TRANSFUSION REACTIONS DUE TO RH INCOMPATIBILITY: MANIFESTATION OF SENSITIVITY TO THE RH FACTOR MANY YEARS AFTER IMMUNIZATION BY PREGNANCY. JAMA. 1945;127(11):627–632. doi:10.1001/jama.1945.02860110007003
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