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August 11, 1951


JAMA. 1951;146(15):1425. doi:10.1001/jama.1951.03670150059016

The belief is widely held that, when a major peripheral artery is ligated or severed, the circulation of the tissues supplied by that artery will be improved if the accompanying vein is ligated simultaneously. This view, which has never been accepted unanimously, has recently been seriously challenged by Simeone, Grillo, and Rundle.1 These authors state that conclusions drawn from the literature have often been unwarranted Some of the clinical results reported by pioneer workers lack statistical significance, and others appear to be distorted by faulty sampling. Subsequent reports have variously confirmed or denied the clinical value of the procedure. Experimental data, likewise, have been contradictory. Even the well-established observation that the residual pressure in a ligated artery can be temporarily raised by occlusion of the accompanying vein is subject to varying interpretations. This rise does not increase the utilization of oxygen in the tissues,2 and according to Simeone