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June 3, 1939

STUDIES IN BLOOD PRESERVATION

Author Affiliations

Assisted by Mary W. Sargent and Ruth Liebhold NEW YORK

Dr. Drew is a Fellow in Surgery, Rockefeller Foundation.; From the Department of Surgical Pathology of Columbia University College of Physicians and Surgeons

JAMA. 1939;112(22):2263-2271. doi:10.1001/jama.1939.02800220029009
Abstract

I. REPARTITION OF POTASSIUM IN CELLS AND PLASMA  Dulière1 reported in 1931 a constant enrichment in the serum potassium of blood kept in contact with cells over a period of days.The manifestations of potassium poisoning have been well known since Blake's2 observation in 1840. The symptoms in both cold3 and warm4 blooded animals have been reported. Such poisoning is not peculiar to the animal kingdom, for alterations in the concentration of potash in certain plant cells or in the mediums in which they live profoundly affect many of their normal reactions.5Because of this, an investigation of the loss of potassium from cells and its increase in the plasma, as one of the abnormalities of stored blood, was felt necessary. An investigation seemed doubly imperative on account of the recent rapid rise of "blood banks," together with the growing conviction that blood kept too

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