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September 30, 1939

SOLUTIONS OF AMORPHOUS INSULIN AND SOLUTIONS OF ZINC INSULIN CRYSTALS: CLINICAL STUDIES ON THE COMPARATIVE SPEED AND DURATION OF ACTION

JAMA. 1939;113(14):1310-1312. doi:10.1001/jama.1939.02800390032008
Abstract

We submit the accompanying blood sugar time data from experiments designed to test the comparative speed and duration of action of solutions of amorphous and crystalline insulin. The data were obtained under the following conditions:

  1. The subjects were eight patients with diabetes of different but previously established degrees of severity. The disease was of moderate severity in three cases and severe in five. In all cases it was of two or more years' duration and no patient had been under observation in the hospital for less than eight days immediately preceding any experiment. All but two patients had been under the supervision of one of us for one or more years.

  2. For at least four days, and usually for from one to two weeks, before any experiment no insulin containing protamine was administered, a constant diet was fed and either two or three injections were given daily of one of the preparations of insulin under investigation. These injections were administered in such a way as to control glycosuria only incompletely and to insure a high value for the blood sugar each morning. No experiment was undertaken until a reasonably constant degree of

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