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October 21, 1939


JAMA. 1939;113(17):1564-1565. doi:10.1001/jama.1939.72800420004008c

Colloidal aluminum hydroxide has been widely used for the treatment of peptic ulcer since Crohn reported its value as an antacid in 1929. There has been little information available concerning any untoward effects. Kraemer1 described frequent constipation and the occurrence of fecal impaction in two cases, but the majority of observers have not mentioned such complications.

The following case illustrates the danger which exists and the unfortunate result which may occur when colloidal aluminum hydroxide is used in the treatment of certain cases of bleeding duodenal ulcer.

M. F., a Negro woman aged 59, a widow, was admitted to the hospital complaining of generalized weakness and intermittent pain in the lower part of the abdomen of two weeks' duration.

There was moderate enlargement of the heart, and the blood pressure was 180 systolic and 110 diastolic. She was treated for hypertensive cardiovascular disease for three weeks. At the end