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October 28, 1939

TREATMENT OF PNEUMOCOCCIC MENINGITIS WITH SULFAPYRIDINE: AND THE SODIUM SALT OF SULFAPYRIDINE

JAMA. 1939;113(18):1614-1619. doi:10.1001/jama.1939.02800430006002
Abstract

Since the demonstration by Whitby1 of the effectiveness of sulfapyridine against pneumococcic infections in mice, many clinical reports have shown that the drug is of definite value in the treatment of pneumonia in man. It appears that the mortality rate from pneumonia in both children and adults is reduced when sulfapyridine is used.2 Reports have appeared which indicate that the drug may be of value also in pneumococcic meningitis.3 However, the number of cases thus far described is so small that one cannot be certain that the prognosis in this disease will be, in general, altered by the use of sulfapyridine. There are published in the literature the records of only fourteen patients with pneumococcic meningitis who were treated with sulfapyridine alone. Eight of the fourteen recovered.

The present communication deals with the use of sulfapyridine and its sodium salt4 in the treatment of seventeen patients with pneumococcic meningitis admitted to the Sydenham Hospital between October 1938 and May 1939. Eight of these seventeen (47 per cent) recovered completely. Antipneumococcic serum

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