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October 28, 1939


JAMA. 1939;113(18):1639-1641. doi:10.1001/jama.1939.72800430002008a

Much interest has been aroused by the advent of sulfapyridine. Although its use has been almost limited to the treatment of pneumonic processes, its efficacy in other conditions has been briefly reported.

Instances of the use of the drug in staphylococcic septicemia or bacteremia of necessity are few and brief. Fenton and Hodgkiss1 reported its use in a case with an atypical clinical picture. A single culture of the blood revealed Staphylococcus aureus. The only significant finding was x-ray evidence of pleural thickening. The temperature dropped markedly twenty-four hours after administration of the drug. O'Brien and McCarthy2 reported staphylococcic bacteremia following furunculosis, with a dramatic drop in temperature and sterile blood culture following therapy with sulfapyridine. Maxwell's3 patient had staphylococcic bacteremia coincidental to pneumonia. Staphylococci were recovered from two cultures of the blood. The temperature dropped to normal in forty-eight hours and culture of the blood became