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The introduction contains a review of the literature of primary disturbances of ossification. This is detailed, covering general conditions such as achondroplasia and cretinism, to localized aseptic necroses, osteochondritis dissecans, osteochondritis deformans coxa (coxa plana) and kyphosis dorsalis juvenilis. The material of the study consists of hereditary anomalies, and the author describes the occurrence of congenital anomalies in six members of a large family. These anomalies are thoroughly studied and elaborately described. They involve multiple joint epiphyses, but especially the metacarpophalangeal articulations, knees, hips and vertebral bodies. The x-ray appearances, which he divides into two principal types, namely anatomic variations and anomalies on the one hand and destructive lesions similar to the osseous aseptic necroses on the other, are most elaborately presented. There are unfortunately no microscopic investigations to correlate with the clinical and x-ray studies. As a monograph on a rather circumscribed subject, built on a comparatively small clinical
Studien über hereditäre, multiple Epiphysenstörungen. JAMA. 1939;113(18):1666. doi:10.1001/jama.1939.02800430058037
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