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November 4, 1939

A NEW METHOD OF TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS: USING SULFAPYRIDINE AND HEPARIN IN COMBINATION: PRELIMINARY REPORT

JAMA. 1939;113(19):1700-1702. doi:10.1001/jama.1939.02800440004002
Abstract

Analysis of 250 cases of subacute bacterial endocarditis with positive blood cultures for alpha (viridans) and, rarely, gamma streptococci in Boston hospitals1 stressed the ineffectiveness of all varieties of therapy prior to the new chemotherapeutic drugs. Sulfanilamide, used in twenty-four cases, and prontosil, used in five, temporarily improved a few; used in four cases, sulfapyridine, although not curative, appeared far more effective. Data that we have collected from other clinics and from one case report concerning sixty-six well studied cases in which intensive treatment was given with sulfapyridine confirm our experience that in most instances the drug lowers the temperature and sterilizes the blood stream but that these effects pass off in from a few days to a month or, rarely, more. Only in one reported case,2 in which the blood cultures were positive for gonococcus and a nonhemolytic anaerobic streptococcus, was there a recovery; the disease followed

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