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November 11, 1939

SMALLPOX VACCINATION OF INFANTSREVACCINATIONS AFTER TWO TO THREE YEARS IN CHILDREN PRIMARILY VACCINATED WITH CULTURE VIRUS (RIVERS), COMPARED WITH THOSE PRIMARILY VACCINATED WITH CALE LYMPH VIRUS

JAMA. 1939;113(20):1796-1800. doi:10.1001/jama.1939.02800450018005
Abstract

Revaccinations of children from 2 to 3 years of age, among those who had been vaccinated1 in 1935 and 1936 in the newborn nurseries of Gallinger Municipal Hospital within a few days of their birth, were done in June and July 1938. The total number of these revaccinated children followed through to involution of the skin reactions numbered seventy, almost exactly half of whom (thirty-six) had had successful primary takes at birth with culture vaccine virus (Rivers) inoculated intradermally, and the other half (thirty-four) had had successful takes at birth with calf lymph virus, two thirds (twenty-three) by the intradermal method and the other third (eleven) by the cutaneous method (Leake's2 multiple pressures). The skin reactions were essentially the same whether the intradermal vaccination had been performed with culture virus (Rivers) or diluted calf lymph virus (New York Bureau of Laboratories) but tended to appear earlier with calf

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