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November 11, 1939


JAMA. 1939;113(20):1807-1808. doi:10.1001/jama.1939.72800450002008a

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To the growing list of diseases in which sulfapyridine may be found of use we should like to add trachoma. In two cases, herewith reported, we have observed astonishing improvement in the chronic form of the disease when treated with sulfapyridine.


Case 1.—  F. F., a white youth aged 15, first seen by us March 11, 1939, had been under treatment for trachoma elsewhere for about one year. Examination showed both corneas markedly opaque. There were no clear areas on either cornea. Vision in both eyes was fingers at 1 foot. Pannus was markedly developed on both corneas. The under surfaces of both upper lids were covered with follicles. The Wassermann and Kahn reactions of the blood were negative. The patient was hospitalized and massive doses of sulfanilamide were given. During the period of hospitalization, covering one month, about 1,000 grains (65 Gm.) of sulfanilamide was given.

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