From experimental observations it is well known that androgenic substances are chemically changed and excreted after entering the circulation. The effectiveness of any androgenic preparation depends on many factors. One of the most important, besides the frequency of administration and the dosage, is the method of administration. The use of various solvents, the addition of fatty acids to the androgenic solutions, esterification of the substances and many other variations have been studied in an attempt to increase the efficiency of administration of androgenic substances. The fact that pure crystalline testosterone is readily absorbed by the body fluids undoubtedly leads to waste when excess material is given. In order to overcome this difficulty and to decrease the rate of absorption, testosterone has usually been injected in an oily solution as the propionate. Injection of testosterone propionate has proved far more effective than the equivalent amounts of free testosterone. The intensity and
VEST SA, HOWARD JE. CLINICAL EXPERIMENTS WITH ANDROGENS: IV. A METHOD OF IMPLANTATION OF CRYSTALLINE TESTOSTERONE. JAMA. 1939;113(21):1869–1872. doi:10.1001/jama.1939.02800460023006
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