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December 2, 1939

ACUTE PERFORATION OF PEPTIC ULCER: IMMEDIATE AND LATE RESULTS IN FIVE HUNDRED CASES

JAMA. 1939;113(23):2015-2019. doi:10.1001/jama.1939.02800480001001
Abstract

In the treatment of acute perforation of peptic ulcer neither the immediate nor the late results are wholly satisfactory. Immediate mortality is distressing and subsequent morbidity often embarrassing. Yet, considering the percentage of deaths when the condition is neglected, one is heartened by the fact that a majority of lives are saved by surgical treatment.

Immediate mortality in peptic ulcer complicated by acute perforation is dependent on many factors. The more important factors are not always under the control of the surgeon. Subsequent morbidity follows perforation largely because in most instances the risk to life is such as to prevent the surgeon's doing anything toward the cure of ulcer at the time of operation. Obviously if improvement in immediate and late results is to be obtained it must be accomplished through better control of the factors which affect morbidity and mortality. As surgeons, we must accept the challenge from the

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