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December 9, 1939

ACUTE OSTEOMYELITIS WITH STAPHYLOCOCCEMIA: A CLINICAL REPORT ON THE USE OF ANTITOXIN IN ITS TREATMENT

JAMA. 1939;113(24):2119-2124. doi:10.1001/jama.1939.02800490015004
Abstract

In 1936 Joyner and Smith1 reported from Duke Hospital excellent results with the use of staphylococcus antitoxin in the treatment of thirteen2 cases of osteomyelitis in which staphylococcemia was present. In their series there were eleven survivals and two deaths as compared with eight survivals and eight deaths in their control group of sixteen similar cases in which therapy was identical except for use of antitoxin.

Previously Dolman3 had reported the results of a series of thirty-two cases of acute staphylococcic osteomyelitis with septicemia which had been treated with staphylococcus antitoxin; in his series there was a mortality rate of 31 per cent. In his control series Dolman, like Joyner and Smith, reported a mortality rate of 50 per cent.

Recently Stookey and Scarpellino4 stated: "It is remarkable that a vast accumulation of experimental facts pertaining to the protective properties of staphylococcic antitoxin against toxin should

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