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December 9, 1939

"EXPERIMENTAL CHEMOTHERAPY WITH SULFANILAMIDE AND RELATED COMPOUNDS"

JAMA. 1939;113(24):2169. doi:10.1001/jama.1939.02800490065023

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Abstract

[An addendum to paper in The Journal November 4]

To the Editor:—  An exception to the specificity of the reaction for the detection of oxidation products of aromatic amines (described in Public Health Reports54:1880 [Oct. 20] 1939) has been found in that positive results were obtained with the glucosides of sulfanilamide and 4,4'-diaminodiphenyl sulfone. Apparently this linkage protects the amino group from acetylation, but the glucoside is later split off by the nitrous acid employed in diazotization.Observations made with the original technic must be interpreted in the light of these observations. Our results on urinary excretion of a hydroxylamine derivative following administration of sulfanilamide must be reexamined to determine to what extent other derivatives were involved in the reaction.Attempts are being made to modify the procedure so that these difficulties will be overcome.

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