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December 9, 1939

Les embolies cérébrales: Études de pathologie expérimentale sur les embolies solide et gazeuse du cerveau

JAMA. 1939;113(24):2176. doi:10.1001/jama.1939.02800490071030

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With the help of a window in the skull of dogs, the authors observed and photographed the pial vessels with a magnification which enabled them to study the arteriolar system and its reaction to cerebral emboli. Solid emboli were produced by the introduction of finely pulverized marble or glass with particles from 80 to 150 microns in diameter into the carotid artery. The immediate reaction to such emboli was a widespread arteriolar spasm, which was present even at a distance from the plugs. These observations were made from the time of embolization up to three hours. In another group of experiments the late vasomotor disturbances from one to 123 days after the embolism were studied. Again there were marked vasospastic phenomena alternating with areas of vasodilatation; the current in the veins was retarded and sometimes reversed. The authors also studied the development of collateral circulation and the "in vivo" appearance

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