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December 16, 1939


JAMA. 1939;113(25):2219-2223. doi:10.1001/jama.1939.02800500025006

This report represents the results of the first eighteen months of our experience in the clinical use of a bismuth preparation for oral administration (sobisminol mass),1 which has been made available through the cooperation of Professor Hanzlik of Stanford University.2 It was supplied in capsules containing the reaction product of sodium bismuthate 0.2 Gm., triisopropanolamine 0.4 Gm., propylene glycol 0.1 Gm. and ethyl alcohol 0.1 Gm. This represents approximately 150 mg. of elemental bismuth. We now report clinical results in ninety cases, including cases of seropositive primary, secondary, late benign (bone, skin, mucous membrane), central nervous system (tabetic, meningovascular) and congenital syphilis.

GENERAL CONSIDERATIONS IN ORAL VERSUS INTRAMUSCULAR THERAPY  There are many obvious facts which make oral administration preferable to any other type as a therapeutic procedure, but with diseases such as syphilis, because of the nature of the drugs which must be used,