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The use of alternating courses of arsenicals, administered intravenously, with intramuscular injections of bismuth compounds in the treatment of syphilis is a standard procedure with many syphilologists. With this therapy the disease is under constant attack by the respective metallic compounds. Physicians who use the injection technic may be assured that the patient has received the prescribed dose. The routine weekly schedule facilitates the observation of the effect of the medication on the disease and on the patient. Regularity of examination and treatment is important to both the patient and the physician. It affords frequent opportunity for mental and moral influence, and encouragement by the physician. It aids in the maintenance of adequate records, which are useful in statistical evaluation of various therapeutic regimens. Perhaps most important to the individual and to society, routine administration of medication provides the physician with an effective means of insuring the prolonged cooperation of
ORAL BISMUTH THERAPY IN SYPHILIS. JAMA. 1939;113(25):2240–2241. doi:10.1001/jama.1939.02800500046012
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