That manganese is not an inert element in relation to some aspects of growth, reproduction and metabolism is fairly certain.1 Elimination of manganese from an otherwise normal experimental diet has been shown to produce sterility in the male and interference with normal lactation in the female.2 A constant constituent of plants, it may have some important functions in their metabolism,3 and it appears that the presence of manganese increases the oxidase reaction. Within certain concentrations it stimulates antitoxin formation,4 the autolysis5 and the respiration6 of animal tissues. Manganese has been found to be present in practically all human tissues.7 It is stored mainly in the liver.7 Absorption from the gastrointestinal tract is slow and incomplete.8 Excretion after oral and subcutaneous administrations is partly in the bile, mainly in the feces and perhaps also through the colon.9 Urinary excretion is very
SULLIVAN M. MANGANESE HYDROXIDE: IN THE TREATMENT OF ACNE VULGARIS, PUSTULAR ACNE, FURUNCULOSIS, SYCOSIS VULGARIS AND PSORIASIS. JAMA. 1940;114(3):246–248. doi:10.1001/jama.1940.62810030006012
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