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January 27, 1940


JAMA. 1940;114(4):344. doi:10.1001/jama.1940.02810040054023

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To the Editor:—  Miss M. C., aged 23, 66 inches (168 cm.) tall and weighing 1961/4 pounds (89 Kg.), presented herself Sept. 18, 1939, because of a typical hypopituitary type of obesity which, she stated, dated from an operation performed six years previously for acute appendicitis. The diagnosis had not been confirmed at operation and along with an appendectomy a right salpingo-oophorectomy had been performed. The patient, in spite of an almost starvation diet, had gained 65 pounds (29.5 Kg.) since the operation.I placed the girl on the regimen suggested by Werner and Weir (Obesity in the Adult, J. Missouri M. A.35:385 [Oct.] 1938), which in brief consists of desiccated thyroid by mouth and intramuscular injections of solution of posterior pituitary. On the patient's first visit she received 10 units of solution of posterior pituitary. In about five minutes she complained of a sense of constriction in

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