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February 10, 1940


JAMA. 1940;114(6):471-474. doi:10.1001/jama.1940.02810060017004

In 1927 Aschheim and Zondek1 reported that the urine of pregnant women contained large amounts of a substance capable of stimulating the ovaries in a manner similar to the action of the gonadotropic principle of the anterior lobe of the pituitary gland. This substance is now known as the anterior pituitary-like hormone. In 1928 these investigators2 published the results of experiments in which they injected into mice the urine of pregnant women. Friedman3 in the following year noted that the ovary of the rabbit likewise responded to injections of urine obtained from pregnant women. In 1931 Friedman and Lapham4 published their application of this fact as a method of diagnosis for pregnancy. A survey of the reports published subsequently emphasizes the high degree of accuracy of the results obtained with the hormonal tests for pregnancy. However, these tests in common with other biologic tests are subject