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March 2, 1940


JAMA. 1940;114(9):821. doi:10.1001/jama.1940.02810090099026

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To the Editor:—  The January 20 issue of The Journal carries a letter by Bernard Seligman citing a case of hypersensitivity to solution of posterior pituitary and mentioning McMann's report in the Oct. 14, 1939, issue. Both cases showed general collapse. I do not know whether urticaria following injection of this substance, but without the collapse symptoms, is rare but cite the following:For the induction of labor, my wife was given 1 minim (0.06 cc.) of solution of posterior pituitary hypodermically, and the injection was followed in ten or fifteen minutes by an urticarial eruption. The eruption was general, caused a great itching and was relieved by epinephrine after half an hour. Following delivery she was given solution of posterior pituitary again by mistake (the nurse had been ordered not to give it); the urticaria again followed and was again relieved by epinephrine. There was no respiratory distress, the

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