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March 16, 1940

STUDIES ON THE MECHANISM OF THE ACTION OF SULFANILAMIDE: IV. THE INFLUENCE OF PROTEOLYTIC PRODUCTS ON THE EFFECTIVENESS OF SULFANILAMIDE

JAMA. 1940;114(11):935-940. doi:10.1001/jama.1940.02810110001001
Abstract

Progress in the synthesis of effective chemotherapeutic agents must await a more thorough understanding of the essential mechanism by which sulfanilamide and related compounds produce their effects on bacteria and the lesions associated with infection.

It was because of this that we began three years ago to study certain of the fundamental factors governing the mode of action of sulfanilamide. The data have been obtained from clinical and experimental investigations, since we believe that the problem can be satisfactorily approached only by a concerted and coordinated study carried on by the same group.

An important conclusion reached during a study of 250 cases of human hemolytic streptococcus infections1 was the fact that sulfanilamide produced its most important effects on diffuse lesions characterized by maximal tissue invasion and minimal tissue destruction. Subsequent investigations have impressed on us the importance of proteolytic products as a rich source of the substances which

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