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In the past five months an attempt was made to observe and evaluate any advantages in a series of cases of pneumonia that might result from administering sodium sulfapyridine intravenously and sulfapyridine intrarectally.
In each case the diagnosis was confirmed by x-ray evidence. Preliminary blood culture and typing and culture of sputum were performed in all cases. The blood levels were determined for all patients save those of the oral group admitted later. These are being mentioned without consideration of blood levels.
Eighteen patients were first treated intravenously, with sodium sulfapyridine. Of these sixteen were treated entirely by the intravenous route.
Thirteen patients were given sulfapyridine by the rectal method alone and one by the oral and rectal methods combined.
The investigation of the intravenous and rectal routes was decided on in an effort to improve on the results of oral treatment noted in sixty cases, thirty of which have
WHITTEMORE WL, ROYSTER CL, RIEDEL PA. INTRAVENOUS AND RECTAL ADMINISTRATION OF SULFAPYRIDINEIN PNEUMOCOCCIC PNEUMONIA. JAMA. 1940;114(11):940–941. doi:10.1001/jama.1940.02810110006002
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