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March 16, 1940

THE USE OF VITAMIN B, FOR THE RELIEF OF PAIN IN VARICOSE ULCERS

JAMA. 1940;114(11):947-948. doi:10.1001/jama.1940.02810110013006
Abstract

Whereas varicose ulcers of the lower extremity are usually accompanied by itching, burning and aching,1 relatively infrequently is the pain severe. Occasionally, however, patients with varicose ulcers are seen who complain bitterly of pain which is little affected by the usually successful therapeutic methods. Because we have secured such splendid results in these cases by the administration of vitamin B1, this presentation is made.

For some time, in the Department of Surgery at Hutchinson Memorial Clinic of Tulane University, all patients with clinical and subclinical avitaminosis, persistent neuritis and painful chronic lesions have been given vitamin B1 (thiamin, Betaxin). It was striking that patients with painful varicose ulcers were relieved shortly after the institution of the vitamin B1 therapy.

Krieg2 had previously (1938) reported results obtained with the use of thiamin. Of the thirty-five patients with varicose ulcers treated with thiamin alone, all but five

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