The regulation of carbohydrate metabolism by certain endocrine glands, notably the pancreas and the hypophysis, has been known for some time, but the complex interrelationship between them is as yet imperfectly understood. The antagonism between the pancreas and the hypophysis is perhaps the best appreciated phase of this activity; however, certain other endocrine glands, notably the thyroid and the adrenal glands, also have a regulatory effect on carbohydrate metabolism. The internal secretion of the pancreas is known to be antidiabetic and to aid in some manner the utilization of dextrose by the tissues; the anterior lobe of the hypophysis, however, possesses a diabetogenic or gluconeogenic principle. It was Houssay's1 publications on the close relationship between the pancreas and the hypophysis that served to stimulate the accumulation of a great mass of experimental data, most of which supports his work.
The Houssay phenomenon refers to (1) the hypersensitivity of hypophysectomized
KOTTE JH, VONDERAHE AR. THE HOUSSAY PHENOMENON IN MAN: REPORT OF A CASE OF DIABETES MELLITUS, INFARCT OF THE ANTERIOR LOBE OF THE PITUITARY BODY AND TERMINAL HYPOGLYCEMIA. JAMA. 1940;114(11):950–953. doi:https://doi.org/10.1001/jama.1940.02810110016008
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