The present report concerns a study, extending over more than a year, of the effects of massive vitamin therapy in the relief of major trigeminal neuralgia in fifty-eight cases of tic douloureux, four cases of sphenopalatine neuralgia and nine cases of "atypical facial neuralgia."
One reason that led us to undertake this study was an experimental and physiologic interest in the possible effectiveness of vitamin B1 in the relief of tic douloureux, in view of the effectiveness of this vitamin in relieving the polyneuritis of chronic alcoholism and pregnancy.
Another reason was the desirability of finding, if possible, some alternative to the most effective treatment yet available for tic douloureux, partial or total section of the sensory root of the gasserian ganglion. Adequate surgical therapy is not available to many sufferers with this disease; in some the pain, though extremely troublesome, is hardly so severe as to persuade the
BORSOOK H, KREMERS MY, WIGGINS CG. THE RELIEF OF SYMPTOMS OF MAJOR TRIGEMINAL NEURALGIA (TIC DOULOUREUX): FOLLOWING THE USE OF VITAMIN B1 AND CONCENTRATED LIVER EXTRACT. JAMA. 1940;114(15):1421–1423. doi:10.1001/jama.1940.02810150007002
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