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April 13, 1940

ASCORBIC ACID IN THE TREATMENT OF CHRONIC LEAD POISONINGREPORT OF A CASE OF CLINICAL FAILURE

JAMA. 1940;114(15):1439-1440. doi:10.1001/jama.1940.62810150001008
Abstract

Holmes, Campbell and Amberg1 recently reported evidence of the value of ascorbic acid in chronic lead poisoning. They administered 100 mg. of ascorbic acid daily to thirty-four workers who suffered clinically from excessive absorption of lead. With this treatment the blood picture as well as the clinical symptoms showed decided improvement. A further study by them of three house painters who suffered from chronic lead poisoning reinforced the conclusions drawn from the study of the factory workers.

The opportunity to study the effect of this vitamin in a case of lead poisoning presented itself to us:

R. M., a white boy aged 27 months, was admitted Sept. 30, 1939, with the following history: His birth was spontaneous and without difficulty. Development appeared to be normal until he was approximately 15 months old, when he began to eat wood, paper and painted articles. Parental control of the abnormal appetite met

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