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April 13, 1940


JAMA. 1940;114(15):1447-1453. doi:10.1001/jama.1940.62810150009009a

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Dr. Harry Gold: The conference this morning is to deal with the routes of administration of drugs. We might do well to confine the discussion to drugs employed for their systemic action. There is hardly a tissue barrier in the body which is not used at one time or another for the transport of a drug into the circulation—the small intestine, the sublingual tissues, the rectal mucous membrane, the intact skin, the subcutaneous tissue, the muscle, the nasal mucosa, the vaginal mucous membrane and the spinal canal. Sometimes we get around all barriers and put the drug directly into the circulation, intravenously, intra-arterially or intra-cardially.

All factors being equal, I think we should probably agree that the oral route is the method of choice for the administration of drugs, as it is for the administration of food. The only trouble is that not all factors are equal, and there are

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