The advisability of using metal plates and screws in the fixation of fractured bones has long been a controversial subject. Hamilton Bailey1 pointed out that metal causes rarefication of bone. Jones and Lieberman2 found that impure metals and alloys of unknown composition gave varying reactions in bone. They also found that rustless steel alloys vary in composition and that there is much soft tissue reaction about the metals used. This reaction they related to metallic corrosion. Rugh3 in his experiments found that iron, steel, copper and zinc, which are readily oxidized by the body fluids, frequently cause aseptic suppuration, while silver, gold and tin were unaffected by body fluids. Venable, Stuck and Beach4 performed extensive experiments and found that electrolysis occurs when different metals are placed in tissues and that pure metals alone are inert. They concluded that electrolytic action causes the formation of irritating metallic
Andre HM, Snyder CH. FIXATION OF FRACTURE WITH METAL PLATE: AN UNUSUAL CASE. JAMA. 1940;114(18):1745. doi:10.1001/jama.1940.62810180002007b
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