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June 1, 1940


JAMA. 1940;114(22):2195-2196. doi:10.1001/jama.1940.02810220019005

Twenty-eight years after the description by Weil in 1886 of a disease characterized by the four cardinal symptoms fever, muscle pains, hemorrhage and jaundice,1 Inada and Ido in 1914 demonstrated a spirochete as the causative organism.2 They also succeeded in curing this disease by serum therapy.3

According to Inada and Ido,3 as soon as the condition has been diagnostically determined the serum treatment should be applied in order to obtain the best results, and a higher rate of recovery accompanies early serum injections. When the serum treatment is given within five days of the disease, recovery is almost certain. Within two to three hours after the treatment with 20 cc. of serum, the causal organism found in the blood almost vanishes.

During the past two decades, numerous cases have been reported in European and Japanese medical journals as mentioned,4 but I have not been able