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June 8, 1940

EXPERIMENTAL HIBERNATION OF METASTATIC GROWTHS: PRELIMINARY REPORT

JAMA. 1940;114(23):2293-2298. doi:10.1001/jama.1940.02810230023006
Abstract

In recent months there has been considerable publicity concerning hibernation or "freezing" in cancer cases. To ascertain the practicability of the method I undertook observations on six cases of hopeless metastatic cancer after visiting the clinic of Dr. Fay and Dr. Smith in Philadelphia and noting the methods they employed in their original observations on the effects of cold in cases of human cancer. In these six cases every known type of treatment had been given without results. It was my aim to observe whether or not hibernation would retard the cancerous process or alleviate the pain.

Fay1 in 1936 first made repeated microscopic studies on the effect of reduced local temperatures on carcinomatous growths, and to him due credit must be given. He presented clinical, pathologic and biologic evidence that temperature plays one of the most important roles in the activation of embryonic cell growth.

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