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December 7, 1963

Council on Drugs

JAMA. 1963;186(10):943-944. doi:10.1001/jama.1963.03710100081016

Evaluation of Two Tranquilizers Acetophenazine Maleate

(Tindal Maleate)

Acetophenazine maleate, a member of the piperazine-substituted group of phenothiazine compounds, is a tranquilizing agent. Clinical studies on the drug available to date represent only a minute fraction of evidence documenting use of phenothiazines; thus, its comparative general value has not been definitely established, and there is insufficient evidence to indicate with certainty whether or not its degree of efficacy in any special situation is superior to that of other phenothiazine agents currently available.

Actions and Uses.  —Acetophenazine maleate is a member of the piperazine group of phenothiazine tranquilizers, but data are insufficient to permit adequate comparisons with actions of other members of the group. Available clinical evidence, obtained mainly from uncontrolled studies, indicates that it may be effective in the treatment of chronic brain syndrome and severe neurotic conditions in which agitation, anxiety, and tension predominate. As with other phenothiazines, it

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