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December 7, 1963

Coexistent Sarcoidosis, Erythema Nodosum, and Gout

JAMA. 1963;186(10):950-952. doi:10.1001/jama.1963.63710100028023

BECAUSE of its multiplicity of tissue involvement, sarcoidosis is a disease which may present in various ways. Arthritis has been reported to occur in 10% to 25% of cases of sarcoidosis and arthritic symptoms may be the first manifestation of the disease.1 Yet this aspect of sarcoidosis has not been sufficiently stressed in the literature. The peripheral joints are primarily affected and the clinical picture may simulate rheumatic fever or rheumatoid arthritis.2, 3 In other instances a polyarthritis is an integral part of the syndrome complex of erythema nodosum. More recently another type of arthritis, gout, has been found by Kaplan and Klatskin4 in association with sarcoidosis. These authors documented cases of three patients with coexistent sarcoidosis, psoriasis, and gout and noted an incidence of hyperuricemia in approximately 20% of patients with sarcoidosis in whom serum uric acid determinations were made.

The following case is of interest