Evaluation of a New Vasopressor Agent
IN 1898, Tigerstedt and Bergman showed that an elevation of blood pressure level was obtained when an extract of rabbit kidney was injected into other animals. This rise was attributed to a substance, renin, found only in renal tissue. In 1934, Goldblatt produced permanent hypertension in dogs by bilateral constriction of the renal arteries, and, in 1940, both Braun-Menendez in Argentina and Page in the US showed that renin itself did not produce peripheral vasoconstriction. They discovered that the interaction of renin with a renin activator substance present in blood plasma was essential for the vasopressor effect. Subsequent work has shown that renin is a proteolytic enzyme which reacts with a serum globulin called hypertensinogen or renin activator. The product of this interaction is a polypeptide with strong pressor and vasoconstrictor properties to which the name angiotensin is applied. In 1954,
Council on Drugs. JAMA. 1963;186(13):1158–1159. doi:10.1001/jama.1963.03710130054014
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