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Clinical Notes
January 11, 1964

Postvaccinial Meningo-EncephalitisIsolation of the Virus from the Brain

JAMA. 1964;187(2):151-153. doi:10.1001/jama.1964.03060150075028

THE ETIOLOGY, pathogenesis, and pathology of postvaccinial encephalitis are subjects of much controversy.1-4 Since isolation of vaccinia virus is not difficult, the reports of failures are impressive. Greenberg and Applebaum, for example, were unsuccessful in attempts to isolate the virus from the brain in three fatal cases of postvaccinial encephalitis,2 and Verlinde failed in six cases.4 On the other hand, vaccinia virus was isolated from the brain in three fatal cases by Blaxall,5 and in two cases by Turnbull and McIntosh.6 Blaxall recovered the virus from the brain, liver, and blood of calves up to the 13th day after vaccination, in rabbits up to the 10th day, and in monkeys up to the 8th day.5 The present communication reports the case of a patient with postvaccinial meningo-encephalitis from whose brain vaccinia virus was isolated and identified.

Report of a Case  This case was studied

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