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Medical News
February 15, 1964

Deaths, Morbidity Not Reduced Thus Far, Oregon Study Shows

JAMA. 1964;187(7):30. doi:10.1001/jama.1964.03060200094048

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To determine the measurable value of long-term anticoagulant therapy after myocardial infarction, four physicians at the University of Oregon Medical School in Portland instituted a controlled double-blindfold study seven years ago.

That study is still in progress, and to date has involved 200 patients. Although a final report is not yet being considered, the principal investigator, Arthur J. Seaman, MD, presented a progress report at the International Symposium on Anticoagulants at Miami Beach last month. His observations on the experiment:

"As yet no reduction in death rate or overall decrease in morbidity has been shown to be conferred by continuous prophylactic anticoagulant therapy post-myocardial infarction."

Seaman, whose colleagues include Herbert E. Griswold, MD, Balph B. Beaume, MD, and Leonard W. Ritzmann, MD, said the trend of the results after sequential analysis has moved in the direction of the as yet unreached conclusion that there is "no difference between anticoagulant therapy and placebo (or control) treatment."

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