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Medical News
February 15, 1964

Morbidity—Not Mortality—Best Criterion For Judging Value of Anticoagulants

JAMA. 1964;187(7):33-34. doi:10.1001/jama.1964.03060200097051

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"Do anticoagulants make a difference? That's the question we're asking," Benjamin Manchester, MD, of George Washington University School of Medicine in Washington, DC, told The Journal.

On the basis of clinical experience and time, he has noted that 15-25% of those who survive an acute coronary occlusion die within the first 12 months while other investigators have recorded an average life span of 43 months following recovery from an acute episode of myocardial infarction, and a 75% mortality within ten years.

In addition, after recovery from an acute myocardial infarction, subsequent coronary occlusion and reinfarction are "inevitable" for the majority.

"As far as I know, no one has demonstrated the ability to prolong life and prevent recurrence—in spite of intensive adherence to popular dietary regimens, estrogens, weight reduction, altered physical activity or reduction of blood cholesterol. Yet there are many patients and some physicians who would lead one to believe

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