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February 22, 1964


JAMA. 1964;187(8):611. doi:10.1001/jama.1964.03060210061018

The complications associated with diabetes often constitute the major clinical and autopsy findings. A report by Norris and Yunis, in the February issue of the Archives of Pathology, suggests that there is a greater prevalence of submucosal degeneration of the seminal vesicles and vasa deferentia associated with aging in diabetics than in normal subjects. Submucosal degeneration is a granular, faintly basophilic change in the connective tissue underlying the epithelium, distinguishable from amyloid deposits. It appears to be particularly more frequent among diabetics of the 70-to-79-year age group (61%) than in control patients of the same age (14%). If the increased incidence of submucosal degeneration in aged diabetics is confirmed, the etiology will probably become a focus of controversy, as is that of amyloid, a substance which it resembles.

Diabetics are also subject to more extensive calcification within the wall of the vas deferens and the walls of the regional small

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