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Multiple Discipline Research Forum
February 29, 1964

Experimental Studies on Prevention of Fatal Pancreatitis

JAMA. 1964;187(9):652-654. doi:10.1001/jama.1964.03060220026008

THE ACTIVATION of large quantities of trypsin is considered to be of major importance in the pathogenesis of acute pancreatitis.1 In animals,2-5 as well as in patients,4,6-11 the course of inflammatory disorders of the pancreas has been favorably influenced by an antitryptic agent (Trasylol). It appears that this drug inhibits the formation of trypsin and other proteolytic enzymes.6

Since in previous investigations use of this compound was followed by a decrease of the mortality in experimentally produced pancreatitis in animals, it could be anticipated to have a prophylactic action as well.4,12 This study was designed to evaluate the prophylactic effect of its antitryptic activity in dogs which were submitted to experimental pancreatitis.

Materials and Methods  Adult mongrel fasting dogs weighing approximately 15 kg (33 lb ) were used. In a control series, acute hemorrhagic pancreatitis was produced in 20 dogs by a modified Elliott technique.13

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