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`The general philosophy under which I work is this: The major impediment to elucidation of cardiovascular control mechanisms is the lack of instrumentation suitable for measuring fundamental cardiovascular variables in the normal animal or human," in the opinion of Dean Franklin, of the Institute for Cardiopulmonary Diseases, Scripps Clinic and Research Foundation in La Jolla, Calif.
"We are now measuring secondary, tertiary, and even lower variables, and the physician's knowledge of disease is based on such data," supplemented by his "wealth of empirically derived information," Franklin told The Journal. In essence, then, diagnosis is a "pattern recognition process," and Franklin contends that "more fundamental cardiologic variables, for example, blood flow, must be measured and standards established for the so-called normal and abnormal individuals before cardiologists "can fully understand the causal mechanisms involved in disease processes."
Regarding the heart as a pump, the physicist would describe it in terms of pressure,
Ultrasound and Physiology. JAMA. 1964;187(9):25–26. doi:10.1001/jama.1964.03060220071036
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