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Featured Clinical Reviews

Original Contribution
April 6, 1964

North American Loxoscelism: Necrotic Bite of the Brown Recluse Spider

Author Affiliations

Little Rock, Ark

From the Division of Dermatology, Department of Medicine, School of Medicine, University of Arkansas, and the Little Rock VA Hospital. Dr. Dillaha is professor of medicine, Dr. Jansen is associate clinical professor of medicine, Dr. Honeycutt is clinical instructor in medicine, and Dr. Hayden is a resident in medicine.

JAMA. 1964;188(1):33-36. doi:10.1001/jama.1964.03060270039008

North American loxoscelism caused by the bite of the Loxosceles reclusus, the brown recluse spider, can produce a gangrenous slough at the site of envenomation and a severe systemic reaction. In 16 cases the local reaction included pain, bleb formation, erythema, ecchymosis, necrosis ending in an eschar, and ulceration. The systemic reactions may include fever, nausea, malaise, hemolysis, and thrombocytopenia. Two deaths have been reported in small children. This spider is indigenous throughout the South Central US.

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