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Medical News & Perspectives
May 11, 1964

Coronary Thrombosis Linked to Fissure In Atherosclerotic Vessel Wall

JAMA. 1964;188(6):35-37. doi:10.1001/jama.1964.03060320157049

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Microscopic examination of the thrombosed portion of coronary arteries from 20 human victims of coronary thrombosis has revealed that in each instance the thrombus was anchored—and had originated—in fissures in the atherosclerotic vessel wall, Paris Constantinides, MD, PhD, of Washington University School of Medicine in St. Louis, told the 48th annual meeting of the Federation of American Societies for Experimental Biology, in Chicago, April 13-17.

Although coronary thrombosis represents the most frequent cause of death among middle-aged and elderly men today, he said, "its immediate cause has always been wrapped up in mystery." It is known, however, that thrombosis occurs only in arteries that show advanced fibrous atherosclerosis, that is in vessels in which the wall has been thickened by collagen-rich plaques, interlaced with varying amounts of fat, he told the conference.

According to Constantinides, cracking of the surface of the atherosclerotic lining is the event underlying both thrombi and

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