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The autoimmune character of at least three experimental diseases (thyroiditis, allergic encephalomyelitis, and aspermatogenesis) "has been established beyond all reasonable doubt," but the precise role of autoantibodies found in sera of patients with pernicious anemia, myasthenia gravis, ulcerative colitis, Addison's disease, and other maladies remains unknown, according to Ernest Witebsky, MD, and Felix Milgrom, MD, of the State University of New York at Buffalo.
Milgrom added, "Some investigators believe that sera of patients suffering from cancer contain so-called cancer antibodies. While there is some possible indication that this is true, convincing evidence in humans is missing."
Only recently, the physicians told The Journal, the concept of autoimmunity has been introduced to explain the pathogenesis of certain diseases of unknown etiology. It has been postulated that in autoimmune disease a structural or functional damage is produced by an immune response against normal components of the body. This represents a proven exception
Spectrum of Autoimmune Diseases: Facts, Factors, and Formulations. JAMA. 1964;189(8):29–31. doi:10.1001/jama.1964.03070080067038
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