GRISEOFULVIN is an antibiotic which has a fungistatic effect against most of the dermatophytes. It can therefore quite logically be expected to be of value in the management of certain superficial fungal infections. By the same token it is, of course, worthless in those cutaneous diseases of other causes which morphologically resemble common mycotic infections. Since griseofulvin therapy often requires considerable time and expense, it is important to establish an etiological diagnosis at the outset. The following three situations demonstrate this point.
A bilateral eczematous eruption involving distal portions of the feet (Fig 1) had its sudden symmetrical onset one month ago. Local treatment with various fungicidal agents merely aggravated the problem. Patch tests to components in the patient's shoes gave a strong delayed eczematous reaction ( 48 hours ) to a sample of the thermoplastic rubber box toe. Complete resolution occurred when a shoe with a plastic toe box was substituted.
Kingery FAJ. Who Will Benefit From Griseofulvin?. JAMA. 1964;190(2):149. doi:10.1001/jama.1964.03070150059014
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